Akkattu T. Biju

Indian Institute of Science

报告时间：10月22日 16：00-17：30

报告地点：4号楼6楼 600会议室

邀请人：马佳佳 副教授

报告人简介

A. T. Biju received his M. Sc. from Sacred Heart College and Ph.D. under the guidance of Dr. Vijay Nair at the CSIR-NIIST. Subsequently, he has been a post-doctoral fellow with Prof. Tien-Yau Luh at the National Taiwan University and an Alexander von Humboldt fellow with Prof. Frank Glorius at the Universität Münster. In 2011, he began his independent research career at the CSIR-National Chemical Laboratory. In 2017, he moved to the Department of Organic Chemistry, Indian Institute of Science, where he is a professor presently. His research focuses on developing strategies using N-heterocyclic carbene (NHC) organocatalysis, and strain-release driven reactions of arynes, donor–acceptor cyclopropanes and bicyclobutanes. He is presently the Associate Editor of Synthesis.

报告摘要

Organocatalysis using N-heterocyclic carbene (NHCs) has been widely utilized for the polarity reversal of aldehydes (umpolung). Although NHC catalysis is well demonstrated for the enantioselective synthesis of target molecules, related application to the synthesis of axially chiral molecules is limited (especially the heteroatom-containing axis). We have recently reported the NHC-catalyzed atroposelective synthesis of C-N axially chiral N-aryl succinimides, phthalimides/maleimides,3 pyridinones, N-N axially chiral 3-amino quinazolinones, indoles and pyrroles as well as C-O axially chiral diarylethers. In addition, precise control over S(VI) and P(V)-stereogenic centers have recently be achieved by the enantioselective synthesis of N-acyl cyclic sulfonimidamides and phosphacycles.