报告人：Prof. Varinder K. Aggarwal

报告人单位：英国皇家科学院院士、 欧洲科学院院士、印度科学院外籍院士University of Bristol

报告时间：2025年7月14日 10:00-11:30

报告地点：霞光楼200室，徐名材报告厅

邀请人：吴晶晶 副教授

报告摘要Abstract

Nature has evolved highly sophisticated machinery for organic synthesis, many of which resemble molecular assembly-line processes. So far chemists have been able to apply this type of approach in the synthesis of peptides, oligonucleotides and polysaccharides but it is much more difficult to apply iterative methodologies to organic synthesis. Here, we describe the application of iterative homologation of boronic esters using chiral lithiated carbamates and chloromethyllithium enabling us to grow carbon chains with control over both relative and absolute stereochemistry. Application of this strategy to the synthesis of the proposed structure of baulamycin and the real structure will be presented as well as other complex targets.

报告人简介Brief introduction

Varinder K. Aggarwal studied chemistry at Cambridge University and received his Ph.D. in 1986 under the guidance of Dr. Stuart Warren. After postdoctoral studies (1986-1988) under Prof. Gilbert Stork, Columbia University, he returned to the UK as a Lecturer at Bath University. In 1991 he moved to Sheffield University, where he was promoted to Professor in in 1997. In 2000 he moved to Bristol University where he holds the Chair in Synthetic Chemistry. He was elected Fellow of the Royal Society in 2012.