报告时间 / Time

11月5日14:00-15:3014:00-15:30, Nov 5, 2024

报告地点 / Location

致远学院光彪楼一楼报告厅（200号）200 Lecture Hall, Zhiyuan College

报告语言 / Language

英语English

报告嘉宾 / Invited Speaker

Kurt Wüthrich

诺贝尔化学奖获得者

美国国家科学院外籍院士

嘉宾简介

Guest Introduction

Kurt Wüthrich was born in Aarberg, Switzerland in 1938 and obtained his Ph.D. in Inorganic Chemistry from the University of Basel, Switzerland in 1964. In 1977, he pioneered the application of two-dimensional nuclear magnetic resonance (2D NMR) to biopolymers, studying amino acids and bovine pancreatic trypsin inhibitor. Based on this work, he developed a method for the complete identification of individual peaks in 1H-NMR spectra of proteins using 2D NMR. Since 1980, he has been the Professor of Biophysics at the ETH Zurich, Zurich, Switzerland, and also serves as the Green Visiting Professor of Structural Biology at Scripps Research, La Jolla, CA, USA. He is additionally a Foreign Associate of the US National Academy of Sciences, a Foreign Associate of the French Academy of Sciences, a Foreign Member of the Latvian Academy of Sciences, and a Foreign Member of the Royal Society, UK. Contributions include the method for macromolecular structure determination with NMR in solution and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology. He was awarded the 2002 Nobel Prize in Chemistry "for the development of methods for determining the three-dimensional structure of biological macromolecules in solution using nuclear magnetic resonance technique."

库尔特·维特里希1938年生于瑞士阿尔贝格，1964年获瑞士巴塞尔大学无机化学博士学位；1977年库尔特·维特里希首先将二维核磁共振的方法用于生物高分子，研究氨基酸和牛胰胰蛋白酶抑制剂，在此基础上发展了用二维核磁共振对蛋白质1H-NMR的单个谱峰全部识别的方法；从1980年起担任瑞士苏黎世联邦理工学院生物物理学教授，还任美国斯克里普斯研究所结构生物学教授。他同时还是美国科学院外籍院士、法兰西科学院外籍院士、拉脱维亚科学院外籍成员和英国皇家学会外籍成员。代表性成果包括在溶液中用核磁共振测定蛋白质结构的方法，以及使用横向弛豫优化光谱(TROSY)原理进行大超分子组装的核磁共振实验。这些技术方法多年来应用在高等生物的分化、免疫抑制和神经病理学等方面的研究。他因“发明了利用核磁共振技术测定溶液中生物大分子三维结构的方法”而获得了2002年的诺贝尔化学奖。

讲座摘要

Abstract

The lecture starts with presentations of results from the present research at the iHuman Institute of ShanghaiTech University, which is focused on allosteric mechanisms of transmembrane signaling by G protein-coupled receptors (GPCRs). This will be followed by some stories about my early days in scientific research and a short description of the project that led to the award of a Nobel Prize in Chemistry.

库尔特·维特里希教授将首先介绍其在上海科技大学iHuman研究所的最新研究成果，该研究集中于G蛋白偶联受体（GPCRs）的跨膜信号传递的异构机制。随后，他将分享一些他早期科学研究的故事，并简要描述关于他获得诺贝尔化学奖的研究工作。