Prof. Shih-Yuan Liu

Department of Chemistry, Boston College

报告时间：2024年7月8日 15:30-17:00

报告地点：6号楼2楼宣讲厅

邀请人：刘家旺 长聘教轨副教授

个人简介：

Prof. Shih-Yuan Liu received his Ph.D. at MIT with Prof. G. C. Fu in 2003, then worked as a postdoc with Prof. D. G. Nocera. He moved to University of Oregon in 2006, and was promoted to Associate Professor in 2012. He joined the Department of Chemistry at Boston College as a Full Professor in 2013. His research interests include the development of boron-nitrogen heterocycles for materials and biomedical applications. He has published >50 JACS, Angew. Chem. and Chem. Soc. Rev. papers. He was the Chair for the 16th Boron Chemistry Meeting, and the US representative to the International Energy Agency (IEA, 2010-2016). He has received the Friedrich Wilhelm Bessel Research Award of the Humboldt Foundation (2016), and Boron in the Americas Award (2018).

报告摘要：

Our recent contributions in the development of alkyne X-boration and hydrofunctionalization reactions that are enabled by 1,4-azaborine-biaryl phosphine (Senphos)-supported Pd catalysts and B(C₆F₅)₃ are described. Specifically, the site- and stereoselective hydroboration, carboration, hydroalkylation, hydroalkynylation, and hydrothiolation of 1,3-enynes will be discussed along with an analysis of possible reaction mechanisms underlying these reactions. Experimental mechanistic data are corroborated by DFT calculations. An outer-sphere oxidative addition reaction where a Pd(0)/Senphos and an electrophile cooperatively activate the 1,3-enyne substrate has emerged as a general mechanism to furnish a Pd-π-allyl species that can engage in subsequent bond forming reactions. However, differences in catalyst resting states and the rate-limiting transition states are observed.