Jin-Quan Yu (余金权) 

  讲席教授 (美国艺术与科学院院士) 

  Scripps Research Institute 

  报告时间：10月24日 9:00-10:10 

  报告地点：闵行校区霞光楼200报告厅 

  邀请人：丁奎岭 院士 商明 长聘教轨副教授

报告摘要 

20-Year Dancing with Palladium and C–H bonds: From Curiosity to IndustrializationThe widespread presence of C–H bonds at various sites of synthetic substrates renders C–H activation the most powerful platform for developing catalytic reactions. To realize the full potential of C–H activation for synthesis, four fundamental challenges must be addressed: developing diverse carbon-carbon and carbon-heteroatom bond forming reactions of diverse poorly reactive native substrates (ReactivitY); enantioselective C–H activation reactions via asymmetric metalation of C–H bonds (EnantioselectivitY); site selective metalation and functionalization of remote C–H bonds (Site-selectivitY); achieving catalytic cycles using sustainable oxidants such as molecular oxygen, aqueous hydrogen peroxides as the terminal oxidants (SustainabilitY). Despite century-long efforts, seeking solutions to these problems has met with limited success due to a fundamental challenge: lack of ligands that can accelerate C–H activation reactions.