Dr. Adam Noble
University of Bristol
邀请人: 吴晶晶 副教授
Organoboron compounds are highly valuable synthetic intermediates in organic chemistry, which also have important applications in medicinal chemistry, with boronic acids and their derivatives being found in several approved pharmaceuticals. As a result, there is a need for synthetic methodologies that can incorporate boron into organic molecules with high efficiency and excellent substrate generality. This lecture will focus on our recent contributions to photoinduced borylation reactions that enable a variety of readily available functional groups to be converted into boronic ester products. Furthermore, the synthetic utility of boronic esters as radical-stabilizing groups and precursors to alkyl radicals in a range of deboronative functionalization reactions will be discussed.
Adam obtained his undergraduate Master’s degree in chemistry from the University of Nottingham in 2008. He completed his PhD with Professor Jim Anderson at University College London (2008-2012) before moving to the USA for a postdoc with Professor Dave MacMillan at Princeton University (2012-2014). He then returned to Prof. Varinder Aggarwal’s group at the University of Bristol as a Postdoc. In 2017, he was promoted to Research Officer in the Aggarwal group, where he took on a leading role in supervising the photochemistry projects within the group. In 2022, he was promoted to Research Fellow (equivalent to Assistant Professor), where he still leads the photochemistry projects within the Aggarwal group as well as directing his own independent research.