课题组长

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商明

职位:长聘教轨副教授,博士生导师

电子邮箱:shangsjtu@sjtu.edu.cn

办公地点:闵行校区化学化工学院霞光楼613

个人网页/课题组主页地址:暂无

研究方向:

  • 基于惰性化学键活化(C–H,C–C,C–N)的新型sp3交叉偶联反应发展

  • 新型手性催化剂的设计与合成及其在不对称sp3交叉偶联中的应用

  • 发展高效绿色的药物合成新工艺用于国家重大需求药物的产业化

教育背景:

  • 2011.09-2016.07  中科院上海有机所,金属有机国家重点实验室,理学博士,导师:余金权(Jin-Quan Yu)教授,戴辉雄研究员

    (其中2015年在美国斯克里普斯研究所学习)

  • 2006.09-2010.07 复旦大学,理学学士

工作经历:

  • 2021.02至今   上海交通大学变革性分子前沿科学中心,长聘教轨副教授

  • 2017.08-2020.08  美国斯克里普斯研究所(Scripps Research Institute,CA),博士后,合作导师:Phil S. Baran 教授

  • 2016.07-2017.08  美国波士顿学院(Boston College),博士后,合作导师:Masayuki Wasa 教授

  • 2011.02-2011.08  中科院上海有机所,生命有机国家重点实验室,研究助理,导师:李昂 研究员

学术任职、荣誉与获奖:

  1. 2022 Thieme Chemistry Journals Award

  2. 2015 上海有机所“汪猷”奖学金

  3. 2015 阿达玛斯学术论文奖,卓越奖

  4. 2014 国家奖学金

  5. 2014 中科院院长优秀奖

  6. 2014 最佳墙报奖, 18届全国金属有机化学会议,兰州

  7. 2009复旦大学人民奖学金

  8. 国际著名学术期刊JACS, ACS Catal., Org. Lett等审稿人

学术成果:

  1. Sun, S.-Z.;# Cai, Y.-M.;# Zhang, D.-L.; Wang, J.-B.; Yao, H.-Q.; Rui, X.-Y.; Martin, R.; Shang, M.* J. Am. Chem. Soc. 2022, 144, 1130.

  2. Xiang, J.;# Shang, M.; # Kawamata, Y.; Lundberg, H.; Reisberg, S.; Chen, M.; Mykhailiuk, P.; Beutner, G.; Gallego, G. M.; Starr, J.; Davies, A.; Paraselli, B.; Blackmond, D. G.; Baran, P. S. “Hindered Dialkyl Ether Synthesis via Electrogenerated Carboncations” Nature, 2019, 573, 398. (# Co-first author)

  3. Shang, M.; # Feu, K. S., # Vantourout, J. C.; Barton, L. M.; Osswald, H. L.; Kato, N.; Gagaring, K.; McNamara, C. W.; Chen, G.; Hu, L.; Ni, S.; Fernández-Canelas, P.; Chen, M.; Merchant, R. R.; Qin, T.; Schreiber, S. L.; Melillo, B.; Yu, J.-Q.; Baran, P. S. “Modular, Stereocontrolled Cβ-H/Cα-C Activation of Alkyl Carboxylic Acids” Proc. Natl. Acad. Sci.. U.S.A. 2019, 116, 8721. (# Co-first author)

  4. Shang, M.; Sun, S.-Z.; Dai, H.-X.; Yu, J.-Q. “Cu(II)-Mediated C–H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles”, J. Am. Chem. Soc. 2014, 136, 3354.

  5. Shang, M.; Sun, S.-Z.; Wang, H.-L.; Laforteza, B.N.; Dai, H.-X.; Yu, J.-Q. “Exceedingly Fast Cu(II)-Promoted ortho-C–H Trifluoromethylation of Arenes with TMSCF3Angew. Chem. Int. Ed. 2014, 53, 10439.

  6. Shang, M.; Wang, H.-L.; Sun, S.-Z.; Dai, H.-X.; Yu, J.-Q. “Cu(II)-Mediated ortho-C–H Alkynylation of (Hetero)Arenes with Terminal Alkynes” J. Am. Chem. Soc. 2014, 136, 11590.

  7. Shang, M.; Wang, X.; Koo, S. M.; Youn, J.; Chan, J. Z.; Yao, W..; Hastings, B. T.; Wasa, M. “Frustrated Lewis Acid/Brønsted Base Catalyst for Direct Enantioselective α-Amination of Carbonyl Compounds” J. Am. Chem. Soc. 2017, 139, 95.

  8. Shang, M.; # Wang, M.-M.; # Saint-Denis, T. G.; Li, M.-H.; Dai, H.-X.; Yu, J.-Q. “Cu-Mediated Late-Stage Functionalization of Heterocycle-Containing Molecules” Angew. Chem. Int. Ed. 2017,56, 5317. (# Co-first author)

  9. Shang, M.; Cao, M.; Wang, Q.; Wasa, M. “Direct Enantioselective Mannich-Type Reaction of Ketones and Esters Using Frustrated Lewis Acid/Brønsted Base Catalyst” Angew. Chem. Int. Ed. 2017, 56, 13338.

  10. Shang, M.; # Chan, J. Z.; # Cao, M.; Chang, Y.; Wang, Q.; Cook, B.; Torker, S.; Wasa, M. “C–H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis” J. Am. Chem. Soc. 2018, 140, 10593. (# Co-first author)

  11. Shang, M.; Shao, Q.; Sun, S.-Z.; Chen, Y.-Q.; Xu, H.; Dai, H.-X.; Yu, J.-Q. “Identification of Monodentate Oxazoline as a Ligand for Copper-Promoted ortho-C–H Hydroxylation and Amination” Chem. Sci. 2017, 8, 1469.

  12. Shang, M.; Sun, S.-Z.; Dai, H.-X.; Yu, J.-Q. “Cu(OAc)2-Catalyzed Coupling of Aromatic C–H Bonds with Arylboron Reagents” Org. Lett. 2014, 16, 5666.

  13. Shang, M.; Zeng, S.-H.; Sun, S.-Z.; Dai, H.-X.; Yu, J.-Q. “Ru(II)-Catalyzed ortho-C–H Amination of Arenes and Hetero-arenes at Room Temperature”, Org. Lett. 2013, 15, 5286.

  14. Shang, M.; Sun, S.-Z.; Wang, H.-L.; Wang, M.-M.; Dai, H.-X. “Recent Progress on Copper-Mediated Directing-Group-Assisted C(sp2)–H Activation” Synthesis. 2016, 48, 4381.

  15. Wang, Jie.; # Shang, M.; # Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond , D. G.; Baran, P. S. “Cu-Catalyzed Decarboxylative Borylation” ACS. Catal. 2018, 8, 9537. (# Co-first author)

  16. Liu, Y.-J.; Xu, H.; Kong, W.-J.; Shang, M.; Dai, H.-X.; Yu, J.-Q. "Overcoming the Limitations of Directed C–H Functionalizations of Heterocycles" Nature 2014, 515, 389.

  17. Chu, L.; Shang, M.; Tanaka, K.; Chen, Q.; Pissarnitski, N.; Streckfuss, E.; Yu, J.-Q. “Remote meta-C−H Activation Using a Pyridine-Based Template: Achieving Site-Selectivity via the Recognition of Distance and Geometry” ACS Cent. Sci. 2015, 1, 394.