课题组长

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李健

职位:长聘教轨副教授

电子邮箱:jianlizcz@sjtu.edu.cn

办公地点:闵行校区化学化工学院霞光楼613室

个人网页/课题组主页地址:

研究方向:

  • 天然产物全合成,手性药物合成

  • 蛋白质定向进化,高活性酶的发现,酶的新型反应性的开发

  • 高效绿色的酶-化学混合合成工艺

教育背景:

  • 2012.09-2017.07  中科院上海有机所,生命有机国家重点实验室,理学博士, 导师:李昂研究员

  • 2007.09-2011.07  兰州大学,理学学士,导师:张辅民教授、涂永强院士

工作经历:

  • 2021.11 至今   上海交通大学变革性分子前沿科学中心,长聘教轨副教授

  • 2018.05-2021.08  美国斯克里普斯研究所,博士后,合作导师:Hans Renata 教授

  • 2017.07-2018.05  中科院上海有机所,生命有机国家重点实验室,研究助理,导师:李昂研究员

学术任职、荣誉与获奖:

  • 2017年 中国科学院朱李月华奖

  • 2016年 中科院“化学与未来”研究生学术论坛 口头报告一等奖

  • 2015年 Junior ACP Lecture Award (Outstanding Lecture Award at the 5th Junior International Conference on Cutting-Edge Organic Chemistry in Asia)


学术成果:

  1. J. Li, F. Li, E. King-Smith, H. Renata,* Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids. Nat. Chem. 2020, 12, 173–179.

  2. P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J. Wang, P. Tian, H.-D. Sun, P.-T. Puno, A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 2020, 142, 13701–13708.

  3. J. Li, X. Zhang, H. Renata,* Asymmetric chemoenzymatic synthesis of podophyllotoxin and related aryltetralin lignans. Angew. Chem. Int. Ed. 2019, 58, 11657–11660.

  4. J. Li, W. Zhang, F. Zhang, Y. Chen, and A. Li,* Total Synthesis of Longeracinphyllin A. J. Am. Chem. Soc. 2017, 139, 14893–14896.

  5. W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A, Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 2018, 140, 4227–4231

  6. Y. Chen, W. Zhang, L. Ren, J. Li, A. Li, Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 2018, 57, 952–956.

  7. Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 2017, 139, 5558–5567.

  8. P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 2016, 55, 6964–6968.

  9. Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 2016, 138, 3982–3985.

  10. X. Xiong, D. Zhang, J. Li, Y. Sun, S. Zhou, M. Yang, H. Shao,* A. Li,* Synthesis of indole terpenoid mimics via a functionality-tolerated Eu(fod)3-catalyzed conjugate addition. Chem. Asian J. 2015, 10, 869–872.

  11. M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nature Communications 2015, 6, 6445.

  12. J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 2014, 136, 16477–16480.

  13. J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 2014, 136, 8185–8188.

  14. J. Deng, R. Li, Y. Luo, J. Li, S. Zhou, Y. Li, J. Hu, A. Li,* Divergent total synthesis of taiwaniaquinones A and F and taiwaniaquinols B and D. Org. Lett. 2013, 15, 2022–2025.

  15. H. Li, F.-M. Zhang, Y.-Q. Tu,* Q.-W. Zhang, Z.-M. Chen, Z.-H. Chen, J. Li, Enantioselective bromination/semipinacol rearrangement for the synthesis of β-bromoketones containing an all-α-carbon quaternary center. Chem. Sci. 2011, 2, 1839–1841.

  16. T. Xu, C. Liang, Y. Cai, J. Li, Y.-M. Li, X.-P. Hui,* Highly enantioselective addition of methyl propiolate to aldehydes catalyzed by a titanium(IV) complex of a β-hydroxy amide. Tetrahedron Asymmetry 2009, 20, 2733–2736.


综述与亮点评述:

  1. Y. Li, J. Li, H. Ding,* and A. Li,* Recent advances on the total synthesis of alkaloids in mainland China. National Science Review 2017, 4, 397–425.

  2. J. Li, A. Amatuni. H. Renata,* Recent advances in the chemoenzymatic synthesis of bioactive natural products. Curr. Opin. Chem. Biol. 2020, 55, 111–118.

  3. J. Li, X. Zhang, H. Renata,* Biocatalytic Oxidative Cyclization with 2-ODD-PH. Trends in Chemistry 2020, 2, 954–955.