课题组长

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凌代舜

职位:教授

电子邮箱:dsling@sjtu.edu.cn

办公地点:

电话:021-

个人网页/课题组主页地址:www.dsling.cn

研究方向:

  • Chemical Biology

  • Assembly/Disassembly Chemistry

  • Molecular Imaging

  • Stimuli-Responsive Biomaterials

  • Nanosensors

  • Dynamic Nanoassembly based Drug Delivery Systems

教育背景:

  • 2009.09-2013.08  Seoul National University,化学与生物工程学院,博士


工作经历:

  • 2021-至今      上海交通大学变革性分子前沿科学中心,教授

  • 2014.12-2020.12  浙江大学,药学院,研究员

  • 2013.08-2014.12  Institute for Basic Science (IBS),博士后

学术任职、荣誉与获奖:

国家优秀青年科学基金获得者,国家重点研发计划青年科学家项目首席科学家,上海市优秀学术带头人,《纳米生物科技》2021年度“未来之星奖”获得者。

主要从事化学生物学、纳米探针、活体成像分析和医学诊疗的研究。以生物体系活体成像分析和疾病精准诊疗为目标,在纳米探针设计、组装调控、多维度精准成像分析等方向取得了系列创新研究成果。迄今,在Nature Nanotechnol., Nature Mater., Nature Biomed. Eng., Nature Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed.,Adv. Mater.等著名国际刊物上发表论文>100篇,他引>8000次。研究成果被多个Nature子刊、Chem. Rev.、Chem. Soc. Rev.等高水平学术期刊正面引用及重点介绍。担任Exploration,J. Control. Release,Science Bulletin,The Innovation,Nano Select等8个国际期刊的副主编或编委。

学术成果:

  • Jianan Liu#, Fangyuan Li#, Yi Wang#, Limin Pan#, Peihua Lin, Bo Zhang, Yanrong Zheng, Yingwei Xu, Hongwei Liao, Giho Ko, Fan Fei, Cenglin Xu, Yang Du, Kwangsoo Shin, Dokyoon Kim, Sung-Soo Jang, Hee Jung Chung, He Tian, Qi Wang, Wei Guo, Jwa-Min Nam, Zhong Chen*, Taeghwan Hyeon*, Daishun Ling*, A Sensitive and Specific Nanosensor for Monitoring Extracellular Potassium Levels in the Brain, Nature Nanotechnology, 2020,15,321-330.

  • Qinjie Weng#,Heng Sun#, Chunyan Fang#, Fan Xia, Hongwei Liao, Jiyoung Lee, Jincheng Wang, An Xie, Jiafeng Ren, Xia Guo, Fangyuan Li,Bo Yang, Daishun Ling*, Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics, Nature Communications, 2021, 2021, 12, 1436.

  • Zeyu Liang#, Qiyue Wang#, Hongwei Liao#, Meng Zhao, Jiyoung Lee, Chuang Yang, Fangyuan Li, Daishun Ling*, Artificially engineered antiferromagnetic nanoprobes for ultra-sensitive histopathological level magnetic resonance imaging, Nature Communications, 2021, 12, 3840.

  • Peihua Lin#, Mengda Cao#, Fan Xia, Hongwei Liao, Heng Sun, Qiyue Wang, Jiyoung Lee, Yan Zhou, Yunan Guan, Cheng Zhang, Zhiqiang Xu, Fangyuan Li*, Ji-Fu Wei*,Daishun Ling*. A Phosphatase-Mimetic Nano-Stabilizer of Mast Cells for Long-Term Prevention of Allergic Disease, Advanced Science, 2021, 2004115.

  • Heng Sun#,Yan Zhong#, Xiandi Zhu#, Hongwei Liao#, Jiyoung Lee, Ying Chen, Lijuan Ma, Jiafeng Ren, Meng Zhao, Mengjiao Tu, Fangyuan Li, Hong Zhang, Mei Tian*, Daishun Ling*,. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease. ACS Nano, 2021, 15(3), 5263-5275.

  • Xi Hu#, Fangyuan Li#, Fan Xia#, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan, Xiyun Yan, Daishun Ling*, Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy, Journal of American Chemical Society, 2020, 142(3), 1636-1644.

  • Jin Wang#, Yinhang Jia#, Qiyue Wang#, Zeyu Liang#, Guangxu Han,, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai*, Daishun Ling*, An Ultra-High Field-Tailored T1-T2 Dual-Mode MRI Contrast Agent for High-Performance Vascular Imaging, Advanced Materials, 2020, e2004917.

  • Fangyuan Li#, Yueping Qiu#, Fan Xia#, Heng Sun, Hongwei Liao, An Xie, Jiyoung Lee, Peihua Lin, Min Wei, Yanfei Shao, Bo Yang, Qinjie Weng*, Daishun Ling*, Dual Detoxification and Inflammatory Regulation by Ceria Nanozymes for Drug-Induced Liver Injury Therapy, Nano Today, 2020, 35, 100925.

  • Xi Hu#, Fan Xia, Jiyoung Lee, Fangyuan Li, Xiaoyang Lu, Xiaozhen Zhuo, Guangjun Nie*, Daishun Ling*, Tailor-Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma, Advanced Science, 2020, 2002545.

  • Meng Zhao#, Zeyu Liang#, Bo Zhang#, Qiyue Wang#, Jiyoung Lee, Fangyuan Li, Qi Wang, Da Ma, Daishun Ling*, A Supramolecular Container-Mediated Surface Engineering Approach for Regulating the Biological Targeting Effect of Nanoparticles, Nano Letters, 2020, 20(11), 7941-7947.

  • Tianyuan Zhang#, Fangyuan Li#, Qianhao Xu#, Qiyue Wang#, Xinchi Jiang#, Zeyu Liang, Hongwei Liao, Xianglei Kong, Jianan Liu, Honghui Wu, Danping Zhang, Changhua An, Liang Dong, Yang Lu, Hongcui Cao, Dokyoon Kim, Jihong Sun, Taeghwan Hyeon, Jianqing Gao*, Daishun Ling*, Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery, Advanced Functional Materials, 2019, 29(24), 1900603.

  • Qinjie Weng#, Xi Hu#, Jiahuan Zheng#, Fan Xia#, Nan Wang, Hongwei Liao, Ying Liu, Dokyoon Kim, Jianan Liu, Fangyuan Li, Qiaojun He, Bo Yang, Chunying Chen, Taeghwan Hyeon, Daishun Ling*, Toxicological Risk Assessments of Iron Oxide Nanocluster-and Gadolinium-Based T1 MRI Contrast Agents in Renal Failure Rats, ACS Nano, 2019, 13(6), 6801-6812.

  • Haibin Wu#, Fangyuan Li#, Wei Shao, Jianqing Gao*, Daishun Ling*, Promoting Angiogenesis in Oxidative Diabetic Wound Microenvironment Using a Nanozyme-Reinforced Self-Protecting Hydrogel, ACS Central Science, 2019, 5(3), 477-485.

  • Jiahe Wu#, Fangyuan Li#, Xi Hu, Jingxiong Lu, Xiaolian Sun, Jianqing Gao*, Daishun Ling*, Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections, ACS Central Science, 2019,5(8), 1366-1376.

  • Fangyuan Li#, Zeyu Liang#, Jianan Liu#, Jihong Sun, Xi Hu, Meng Zhao, Jiaxin Liu, Ruiliang Bai, Dokyoon Kim, Xiaolian Sun, Taeghwan Hyeon, Daishun Ling*, Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors, Nano Letters, 2019, 19(7), 4213-4220.

  • Jingxiong Lu, Jihong Sun, Fangyuan Li, Jin Wang, Jianan Liu, Dokyoon Kim, Chunhai Fan, Taeghwan Hyeon, Daishun Ling*, Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies,Journal of American Chemical Society, 2018, 140 (32), 10071–10074.

  • Fangyuan Li#, Yang Du#, Jianan Liu#, Heng Sun, Jin Wang, Ruiqing Li, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling*, Responsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapy of Deep Tumors, Advanced Materials, 2018, 30(35), 1802808.

  • Xi Hu#, Jihong Sun#, Fangyuan Li#, Ruiqing Li, Jiahe Wu, Jie He, Nan Wang, Jianan Liu, Shuaifei Wang, Fei Zhou, Xiaolian Sun, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling*, Renal-Clearable Hollow Bismuth Subcarbonate Nanotubes for Tumor Targeted Computed Tomography Imaging and Chemoradiotherapy, Nano Letters, 2018, 18, 1196-1204.

  • Yang Lu#, Yunjun Xu#, Guobing Zhang#, Daishun Ling#, Mingquan Wang, Yong Zhou, YaDong Wu, Tao Wu, Michael J. Hackett, Byung Hyo Kim, Hogeun Chang, Jonghoon Kim, Xintian Hu, Liang Dong, Nohyun Lee, Fangyuan Li, Jiacai He, Li Zhang, Huiqin Wen, Bo Yang, Seung Hong Choi*, Taeghwan Hyeon*, Duohong Zou*, Iron Oxide Nanoclusters for T1 Magnetic Resonance Imaging of Non-Human Primates, Nature Biomedical Engineering, 2017, 1(8), 637-643.

  • Fangyuan Li, Jingxiong Lu, Xueqian Kong, Taeghwan Hyeon, Daishun Ling*, Dynamic Nanoparticle Assemblies for Biomedical Applications, Advanced Materials, 2017, 29(14), 1605897.